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4.
Hipertens. riesgo vasc ; 39(3): 128-134, jul-sep 2022. tab
Artigo em Espanhol | IBECS | ID: ibc-204045

RESUMO

Olmesartán es un potente antagonista de los receptores de la angiotensina II utilizado habitualmente en el tratamiento de la hipertensión arterial. Durante la última década se han descrito varios casos de enteropatía tipo esprúe asociados al uso de este fármaco, con afectación clínica severa que precisan hospitalización, pero afortunadamente con remisión completa tras la retirada del mismo. Se presenta el caso de una mujer de 82 años pluripatológica, con un síndrome diarreico crónico que derivó en una pérdida de 20kg de peso en los últimos tres meses. Para su hipertensión seguía doble terapia: olmesartán 40mg y lercanidipino 10mg/día. Basado en los hallazgos de la paciente presentada, se realiza una búsqueda bibliográfica de todos los casos publicados en revistas indexadas españolas (PubMed) y se comparan, intentando establecer un perfil de sospecha que promueva la suspensión de olmesartán y acelere las pruebas complementarias necesarias para descartar otros diagnósticos.(AU)


Olmesartan is a potent angiotensin II receptor antagonist commonly used in the treatment of high blood pressure. During the last decade, several cases of sprue-like enteropathy have been described associated with the use of this drug - with severe clinical involvement that requires hospitalization - but fortunately with complete remission after its discontinuation. We present the case of a multi-pathological 82-year-old woman with a chronic diarrhoeal syndrome that resulted in a weight loss of 20kg over the last three months. She was prescribed dual therapy for her hypertension: olmesartan 40mg, torasemide 10mg, and lercanidipine 10mg/day. Based on the findings of the patient presented, we conducted a literature search of all the cases published in Spanish indexed journals (PubMed) and compared them, attempting to establish a suspicion profile that would result in the suspension of olmesartan and accelerate the complementary tests necessary to rule out other diagnoses.(AU)


Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Olmesartana Medoxomila/efeitos adversos , Olmesartana Medoxomila/análise , Hipertensão , Diarreia , Mulheres , Idoso de 80 Anos ou mais
6.
Hipertens Riesgo Vasc ; 39(3): 128-134, 2022.
Artigo em Espanhol | MEDLINE | ID: mdl-35058164

RESUMO

Olmesartan is a potent angiotensin II receptor antagonist commonly used in the treatment of high blood pressure. During the last decade, several cases of sprue-like enteropathy have been described associated with the use of this drug - with severe clinical involvement that requires hospitalization - but fortunately with complete remission after its discontinuation. We present the case of a multi-pathological 82-year-old woman with a chronic diarrhoeal syndrome that resulted in a weight loss of 20kg over the last three months. She was prescribed dual therapy for her hypertension: olmesartan 40mg, torasemide 10mg, and lercanidipine 10mg/day. Based on the findings of the patient presented, we conducted a literature search of all the cases published in Spanish indexed journals (PubMed) and compared them, attempting to establish a suspicion profile that would result in the suspension of olmesartan and accelerate the complementary tests necessary to rule out other diagnoses.


Assuntos
Doença Celíaca , Hipertensão , Idoso de 80 Anos ou mais , Diarreia/patologia , Feminino , Humanos , Hipertensão/tratamento farmacológico , Imidazóis/efeitos adversos , Tetrazóis/efeitos adversos
20.
Hipertens. riesgo vasc ; 31(4): 132-142, oct.-dic. 2014. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-129660

RESUMO

Las crisis hipertensivas se definen como elevaciones agudas de la presión arterial capaces de producir alteraciones funcionales o estructurales en los órganos diana de la hipertensión. Históricamente se han dividido en 2 tipos, urgencias y emergencias hipertensivas, con diferente clínica, tratamiento y pronóstico. En esta revisión se sigue dicha clasificación pero considerando un tercer tipo, las llamadas seudocrisis o falsas crisis hipertensivas. Las urgencias hipertensivas no provocan afectación de los órganos diana o si esta se produce es leve-moderada, permitiendo un descenso tensional lento y progresivo (horas-días) con fármacos por vía oral, habitualmente en el ámbito extrahospitalario. Las emergencias hipertensivas provocan lesiones agudas y graves de los órganos diana, con riesgo de compromiso vital, precisando un descenso tensional rápido (minutos-horas) pero muy controlado con fármacos por vía intravenosa en el ámbito hospitalario. Las elevaciones tensionales agudas que no pueden llegar a clasificarse ni como urgencias ni como emergencias se consideran seudocrisis hipertensivas


Hypertensive crises are defined as acute blood pressure elevations that can cause functional or structural alterations in hypertension target organs. Historically, they have been divided into two types, urgencies and hypertensive emergencies, with different symptoms, treatment and prognosis. This review follows this classification but also considers a third type, the so-called pseudocrises or false hypertensive crisis. Hypertensive urgencies do not cause organ involvement target or if this does occur, the involvement is slight-moderate, allowing a slow and progressive decrease in pressure (hours-days) with oral drugs usually in the outpatient setting (primary care).Hypertensive emergencies cause acute and severe injuries of the target organs, with life threatening risk, and require a rapid, but very controlled drop with intravenous drugs in blood pressure (minutes-hours) within the hospital setting. Acute blood pressure elevations that cannot be classified as urgencies or emergencies are considered hypertensive pseudocrises


Assuntos
Humanos , Hipertensão/complicações , Hipertensão Maligna/diagnóstico , Tratamento de Emergência/métodos , Fatores de Risco , Órgãos em Risco/fisiopatologia
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